immunoglobulin superfamily meaning in English

免疫球蛋白超家族,免疫球蛋白大家族

It is interesting that pma plus calcium ionophore a23187 can inhibit pma - induced pta1 expression , and this effect ca n ' t be reversed by calcmeurin inhibiter fk506 . pta1 mabs can inhibit ctl activation and differentiation in mixed lymphocyte culture system when added at the beginning of the culture but can induce platelet activation and aggregation in the fc dependent manner . in 1997 , pta1 cdna was cloned from cdna library of tpa activated jurkat cells , which belongs to immunoglobulin superfamily ( igsf ) with two v - like domains of extracelluar region of pta1
Il - 2 、 tnf - 、 pma可以使t细胞pta1表达上调， tgf -可以下调pta1的表达，而pma加上钙离子载体a23187可以显著抑制pma的上调作用，且这种抑制作用不被calcineurin抑制剂fk506所逆转， 1997年burns教授从pma活化的jurkat细胞cdna文库中克隆了pta1cdna全长，证实pta1是一个新分子，属于免疫球蛋白超家族，胞膜外区有两个v样结构域。